UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries

UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries

Ultraviolet (UV) filters are chemicals widely used in personal care products (PCPs). Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, n...

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Bibliographic Details
Main Authors: Margarida Lorigo, Carla Quintaneiro, Manuel C. Lemos, José Martinez-de-Oliveira, Luiza Breitenfeld, Elisa Cairrao
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
UV-B filter
endocrine disruptor compound
human umbilical artery
vascular smooth muscle cells
relaxation
L-Type VOCC
soluble guanylyl cyclase
organ bath
planar cell surface area
Online Access:http://www.mdpi.com/1422-0067/20/6/1376

Internet

http://www.mdpi.com/1422-0067/20/6/1376

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