UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries
Ultraviolet (UV) filters are chemicals widely used in personal care products (PCPs). Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, n...
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doaj-bde9598226dd49ab9d81c12ddc5d16752020-11-24T21:36:39ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-03-01206137610.3390/ijms20061376ijms20061376UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical ArteriesMargarida Lorigo0Carla Quintaneiro1Manuel C. Lemos2José Martinez-de-Oliveira3Luiza Breitenfeld4Elisa Cairrao5CICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, PortugalDepartment of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, PortugalCICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, PortugalCICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, PortugalCICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, PortugalCICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, PortugalUltraviolet (UV) filters are chemicals widely used in personal care products (PCPs). Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, no studies assessed the UV filters effects as human EDCs at the vascular level. Octylmethoxycinnamate (OMC) is the world’s most widely used UV-B filter, present in more than 90% of PCPs. Due to its demonstrated multiple hormonal activities in animal models, this substance is also suspected to be a human EDC. The purpose of this study was to assess the rapid/short-term effects of OMC on arterial tonus and analyse its mode of action (MOA). Using human umbilical arteries, the endocrine effects of OMC were evaluated in in vitro (cellular and organ) experiments by planar cell surface area (PCSA) and organ bath, respectively. Our data show that OMC induces a rapid/short-term smooth muscle relaxation acting through an endothelium-independent MOA, which seems to be shared with oestrogens, involving an activation of soluble guanylyl cyclase (sGC) that increases the cyclic guanosine monophosphate (cGMP) intracellular levels and an inhibition of L-type voltage-operated Ca2+ channels (L-Type VOCC).http://www.mdpi.com/1422-0067/20/6/1376UV-B filterendocrine disruptor compoundhuman umbilical arteryvascular smooth muscle cellsrelaxationL-Type VOCCsoluble guanylyl cyclaseorgan bathplanar cell surface area |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Margarida Lorigo Carla Quintaneiro Manuel C. Lemos José Martinez-de-Oliveira Luiza Breitenfeld Elisa Cairrao |
spellingShingle |
Margarida Lorigo Carla Quintaneiro Manuel C. Lemos José Martinez-de-Oliveira Luiza Breitenfeld Elisa Cairrao UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries International Journal of Molecular Sciences UV-B filter endocrine disruptor compound human umbilical artery vascular smooth muscle cells relaxation L-Type VOCC soluble guanylyl cyclase organ bath planar cell surface area |
author_facet |
Margarida Lorigo Carla Quintaneiro Manuel C. Lemos José Martinez-de-Oliveira Luiza Breitenfeld Elisa Cairrao |
author_sort |
Margarida Lorigo |
title |
UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries |
title_short |
UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries |
title_full |
UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries |
title_fullStr |
UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries |
title_full_unstemmed |
UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibition and Guanylyl Cyclase Activation in Human Umbilical Arteries |
title_sort |
uv-b filter octylmethoxycinnamate induces vasorelaxation by ca2+ channel inhibition and guanylyl cyclase activation in human umbilical arteries |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-03-01 |
description |
Ultraviolet (UV) filters are chemicals widely used in personal care products (PCPs). Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, no studies assessed the UV filters effects as human EDCs at the vascular level. Octylmethoxycinnamate (OMC) is the world’s most widely used UV-B filter, present in more than 90% of PCPs. Due to its demonstrated multiple hormonal activities in animal models, this substance is also suspected to be a human EDC. The purpose of this study was to assess the rapid/short-term effects of OMC on arterial tonus and analyse its mode of action (MOA). Using human umbilical arteries, the endocrine effects of OMC were evaluated in in vitro (cellular and organ) experiments by planar cell surface area (PCSA) and organ bath, respectively. Our data show that OMC induces a rapid/short-term smooth muscle relaxation acting through an endothelium-independent MOA, which seems to be shared with oestrogens, involving an activation of soluble guanylyl cyclase (sGC) that increases the cyclic guanosine monophosphate (cGMP) intracellular levels and an inhibition of L-type voltage-operated Ca2+ channels (L-Type VOCC). |
topic |
UV-B filter endocrine disruptor compound human umbilical artery vascular smooth muscle cells relaxation L-Type VOCC soluble guanylyl cyclase organ bath planar cell surface area |
url |
http://www.mdpi.com/1422-0067/20/6/1376 |
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