Gomisin M2 Inhibits Mast Cell-Mediated Allergic Inflammation via Attenuation of FcεRI-Mediated Lyn and Fyn Activation and Intracellular Calcium Levels

Gomisin M2 Inhibits Mast Cell-Mediated Allergic Inflammation via Attenuation of FcεRI-Mediated Lyn and Fyn Activation and Intracellular Calcium Levels

Mast cells are effector cells that induce allergic inflammation by secreting inflammatory mediators. Gomisin M2 (G.M2) is a lignan isolated from Schisandra chinensis (Turcz). Baill. exhibiting anti-cancer activities. We aimed to investigate the anti-allergic effects and the underlying mechanism of G...

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Bibliographic Details
Main Authors: Hima Dhakal, Soyoung Lee, Eun-Nam Kim, Jin Kyeong Choi, Min-Jong Kim, Jinjoo Kang, Young-Ae Choi, Moon-Chang Baek, Byungheon Lee, Hyun-Shik Lee, Tae-Yong Shin, Gil-Saeng Jeong, Sang-Hyun Kim
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Pharmacology
Subjects:
mast cells
allergic inflammation
anaphylaxis
calcium
Gomisin M2
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00869/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00869/full

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