β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans.

β-Integrin de-phosphorylation by the Density-Enhanced Phosphatase DEP-1 attenuates EGFR signaling in C. elegans.

Density-Enhanced Phosphatase-1 (DEP-1) de-phosphorylates various growth factor receptors and adhesion proteins to regulate cell proliferation, adhesion and migration. Moreover, dep-1/scc1 mutations have been detected in various types of human cancers, indicating a broad tumor suppressor activity. Du...

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Bibliographic Details
Main Authors: Michael Walser, Christoph Alois Umbricht, Erika Fröhli, Paolo Nanni, Alex Hajnal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5305270?pdf=render

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http://europepmc.org/articles/PMC5305270?pdf=render

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