Transgenic mice over-expressing ET-1 in the endothelial cells develop systemic hypertension with altered vascular reactivity.

Transgenic mice over-expressing ET-1 in the endothelial cells develop systemic hypertension with altered vascular reactivity.

Endothelin-1 (ET-1) is a potent vasoconstrictor involved in the regulation of vascular tone and implicated in hypertension. However, the role of small blood vessels endothelial ET-1 in hypertension remains unclear. The present study investigated the effect of chronic over-expression of endothelial E...

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Bibliographic Details
Main Authors: Justin Wai-Chung Leung, Wing Tak Wong, Hon Wai Koon, Fong Ming Mo, Sidney Tam, Yu Huang, Paul M Vanhoutte, Stephen Sum Man Chung, Sookja Kim Chung
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3214015?pdf=render

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http://europepmc.org/articles/PMC3214015?pdf=render

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