Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABA<sub>A</sub> Receptor

Anti-Epileptic Effects of FABP3 Ligand MF1 through the Benzodiazepine Recognition Site of the GABA<sub>A</sub> Receptor

Recently, we developed the fatty acid-binding protein 3 (FABP3) ligand MF1 (4-(2-(1-(2-chlorophenyl)-5-phenyl-1H-pyrazol-3-yl)phenoxy) butanoic acid) as a therapeutic candidate for α-synucleinopathies. MF1 shows affinity towards γ-aminobutyric acid type-A (GABA<sub>A</sub>) receptor, but...

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Bibliographic Details
Main Authors: Yasushi Yabuki, Jiaqi Liu, Ichiro Kawahata, Hisanao Izumi, Yasuharu Shinoda, Kohei Koga, Shinya Ueno, Norifumi Shioda, Kohji Fukunaga
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
GABA<sub>A</sub> receptor
anti-epileptic effect
benzodiazepine recognition site
Online Access:https://www.mdpi.com/1422-0067/21/15/5525

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https://www.mdpi.com/1422-0067/21/15/5525

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