Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells.

Increased aortic calpain-1 activity mediates age-associated angiotensin II signaling of vascular smooth muscle cells.

Angiotensin II (Ang II) signaling, including matrix metalloproteinase type II (MMP2) activation, has been linked to an age-associated increase in migration capacity of vascular smooth muscle cells (VSMC), and to other proinflammatory features of arterial aging. Calpain-1 activation is required for M...

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Bibliographic Details
Main Authors: Liqun Jiang, Mingyi Wang, Jing Zhang, Robert E Monticone, Richard Telljohann, Gaia Spinetti, Gianfranco Pintus, Edward G Lakatta
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-05-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2373882?pdf=render

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http://europepmc.org/articles/PMC2373882?pdf=render

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