Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERK1/2 aggravates cancer-induced bone destruction

Inflammatory conversion of quiescent osteoblasts by metastatic breast cancer cells through pERK1/2 aggravates cancer-induced bone destruction

Abstract Disruption of bone homeostasis caused by metastatic osteolytic breast cancer cells increases inflammatory osteolysis and decreases bone formation, thereby predisposing patients to pathological fracture and cancer growth. Alteration of osteoblast function induces skeletal diseases due to the...

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Bibliographic Details
Main Authors: Jungho Back, Minh Nam Nguyen, Lu Li, Saelim Lee, Inkyu Lee, Fancheng Chen, Lauren Gillinov, Yeon-Ho Chung, Kareme D. Alder, Hyuk-Kwon Kwon, Kristin E. Yu, Christopher M. Dussik, Zichen Hao, Michael J. Flores, Yoseph Kim, Izuchukwu K. Ibe, Alana M. Munger, Sung Wook Seo, Francis Y. Lee
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-021-00158-w

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https://doi.org/10.1038/s41413-021-00158-w

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