Species-Specific Structural Requirements of Alpha-Branched Trehalose Diester Mincle Agonists

Species-Specific Structural Requirements of Alpha-Branched Trehalose Diester Mincle Agonists

Despite the ever present need for an effective Mycobacterium tuberculosis (Mtb) vaccine, efforts for development have been largely unsuccessful. Correlates of immune protection against Mtb are not wholly defined, but Th1 and likely Th17 adaptive immune responses have been demonstrated to be necessar...

Full description

Bibliographic Details
Main Authors: Alyson J. Smith, Shannon M. Miller, Cassandra Buhl, Robert Child, Margaret Whitacre, Roman Schoener, George Ettenger, David Burkhart, Kendal Ryter, Jay T. Evans
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Immunology
Subjects:
mincle receptor
trehalose diester
Mycobacterium tuberculosis
C type lectin receptor
adjuvant
Th17
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00338/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00338/full

Similar Items