Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)

Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)

Currently no approved treatment exists for fibrodysplasia ossificans progressiva (FOP) patients, and disease progression results in severe restriction of joint function and premature mortality. LDN-193189 has been demonstrated to be efficacious in a mouse FOP disease model after oral administration....

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Bibliographic Details
Main Authors: Elias C. Padilha, Jianyao Wang, Ed Kerns, Arthur Lee, Wenwei Huang, Jian-kang Jiang, John McKew, Abdul Mutlib, Rosangela G. Peccinini, Paul B. Yu, Philip Sanderson, Xin Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
metabolite identification
fibrodysplasia ossificans progressiva
structure optimization
aldehyde oxidase
reactive metabolite
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00234/full

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https://www.frontiersin.org/article/10.3389/fphar.2019.00234/full

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