Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression

Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression

Heart failure is a major public health issue but due to our poor disease understanding the current therapies are symptomatic. Here the authors identify Myoscape as a novel cardiac protein regulating membrane localization of the L-type calcium channel and heart's contractile force, thus promisin...

Full description

Bibliographic Details
Main Authors: Matthias Eden, Benjamin Meder, Mirko Völkers, Montatip Poomvanicha, Katrin Domes, M. Branchereau, P. Marck, Rainer Will, Alexander Bernt, Ashraf Rangrez, Matthias Busch, German Mouse Clinic Consortium, Martin Hrabě de Angelis, Christophe Heymes, Wolfgang Rottbauer, Patrick Most, Franz Hofmann, Norbert Frey
Format: Article
Language:English
Published: Nature Publishing Group 2016-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11317

Internet

https://doi.org/10.1038/ncomms11317

Similar Items