Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns
Abstract Background Fragile X syndrome (FXS), a neurodevelopmental disorder, is a leading monogenetic cause of intellectual disability and autism spectrum disorder. Notwithstanding the extensive studies using rodent and other pre-clinical models of FXS, which have provided detailed mechanistic insig...
Main Authors: | , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2020-06-01
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Series: | Molecular Autism |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13229-020-00351-4 |