Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns

Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns

Abstract Background Fragile X syndrome (FXS), a neurodevelopmental disorder, is a leading monogenetic cause of intellectual disability and autism spectrum disorder. Notwithstanding the extensive studies using rodent and other pre-clinical models of FXS, which have provided detailed mechanistic insig...

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Main Authors: Shreya Das Sharma, Rakhi Pal, Bharath Kumar Reddy, Bhuvaneish T. Selvaraj, Nisha Raj, Krishna Kumar Samaga, Durga J. Srinivasan, Loren Ornelas, Dhruv Sareen, Matthew R. Livesey, Gary J. Bassell, Clive N. Svendsen, Peter C. Kind, Siddharthan Chandran, Sumantra Chattarji, David J. A. Wyllie
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Molecular Autism
Subjects:
Fragile X syndrome
Disease-modelling
Electrophysiology
Action potential
Online Access:http://link.springer.com/article/10.1186/s13229-020-00351-4

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