Natural Course of Activated Phosphoinositide 3-Kinase Delta Syndrome in Childhood and Adolescence

Natural Course of Activated Phosphoinositide 3-Kinase Delta Syndrome in Childhood and Adolescence

Activated phosphoinositide 3-kinase delta syndrome (APDS), caused by mutations in PI3Kδ catalytic p110δ (PIK3CD) or regulatory p85α (PIK3R1) subunits, is a primary immunodeficiency affecting both humoral and cellular immunity, which shares some phenotypic similarities with hyper-IgM syndromes and co...

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Bibliographic Details
Main Authors: Marketa Bloomfield, Adam Klocperk, Radana Zachova, Tomas Milota, Veronika Kanderova, Anna Sediva
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pediatrics
Subjects:
APDS
immunoglobulins
lymphoproliferation
immunodeficiency
infection
PI3K
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2021.697706/full

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https://www.frontiersin.org/articles/10.3389/fped.2021.697706/full

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