Metformin does not compromise energy status in human skeletal muscle at rest or during acute exercise: A randomised, crossover trial

Metformin does not compromise energy status in human skeletal muscle at rest or during acute exercise: A randomised, crossover trial

Abstract 5´AMP–activated protein kinase (AMPK) is a mediator of a healthy metabolic phenotype in skeletal muscle. Metformin may exacerbate the energy disturbances observed during exercise leading to enhanced AMPK activation, and these disturbances may provoke early muscular fatigue. We studied acute...

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Bibliographic Details
Main Authors: Jonas M. Kristensen, Christian Lillelund, Rasmus Kjøbsted, Jesper B. Birk, Nicoline R. Andersen, Lars Nybo, Karin Mellberg, Anudharan Balendran, Erik A. Richter, Jørgen F. P. Wojtaszewski
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Physiological Reports
Subjects:
Akt
AMPK activity
exercise
insulin sensitivity
metformin content in muscle
TBC1D1
Online Access:https://doi.org/10.14814/phy2.14307

Internet

https://doi.org/10.14814/phy2.14307

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