TRIB2 desensitizes ferroptosis via βTrCP-mediated TFRC ubiquitiantion in liver cancer cells

TRIB2 desensitizes ferroptosis via βTrCP-mediated TFRC ubiquitiantion in liver cancer cells

Abstract Tribbles homolog 2 (TRIB2) is known to boost liver tumorigenesis via regulating Ubiquitin (Ub) proteasome system (UPS). At least two ways are involved, i.e., acts as an adaptor protein to modulate ubiquitination functions of certain ubiquitin E3 ligases (E3s) and reduces global Ub levels vi...

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Bibliographic Details
Main Authors: Susu Guo, Yuxin Chen, Xiangfei Xue, Yueyue Yang, Yikun Wang, Shiyu Qiu, Jiangtao Cui, Xiao Zhang, Lifang Ma, Yongxia Qiao, Jiayi Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-021-00574-1

Internet

https://doi.org/10.1038/s41420-021-00574-1

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