Inhibition of junctional adhesion molecule-A/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia/reperfusion injury

Inhibition of junctional adhesion molecule-A/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia/reperfusion injury

Proinflammatory mediators trigger intensive postischemic inflammatory remodeling of the blood–brain barrier (BBB) including extensive brain endothelial cell surface and junctional complex changes. Junctional adhesion molecule-A (JAM-A) is a component of the brain endothelial junctional complex with...

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Bibliographic Details
Main Authors: Nikola Sladojevic, Svetlana M. Stamatovic, Richard F. Keep, Jamison J. Grailer, J. Vidya Sarma, Peter A. Ward, Anuska V. Andjelkovic
Format: Article
Language:English
Published: Elsevier 2014-07-01
Series:Neurobiology of Disease
Subjects:
Tight junctions
JAM-A
Stroke
Inflammation
Blood–brain barrier
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114000710

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http://www.sciencedirect.com/science/article/pii/S0969996114000710

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