Role of phosphate limitation and pyruvate decarboxylase in rewiring of the metabolic network for increasing flux towards isoprenoid pathway in a TATA binding protein mutant of Saccharomyces cerevisiae

Role of phosphate limitation and pyruvate decarboxylase in rewiring of the metabolic network for increasing flux towards isoprenoid pathway in a TATA binding protein mutant of Saccharomyces cerevisiae

Abstract Background Production of isoprenoids, a large and diverse class of commercially important chemicals, can be achieved through engineering metabolism in microorganisms. Several attempts have been made to reroute metabolic flux towards isoprenoid pathway in yeast. Most approaches have focused...

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Bibliographic Details
Main Authors: Manisha Wadhwa, Sumana Srinivasan, Anand K. Bachhawat, K. V. Venkatesh
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Microbial Cell Factories
Subjects:
SPT15
Metabolic flux distribution
Phosphate
NADPH
Isoprenoid pathway
PDC6
Online Access:http://link.springer.com/article/10.1186/s12934-018-1000-1

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http://link.springer.com/article/10.1186/s12934-018-1000-1

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