Human glutathione-S-transferase pi potentiates the cysteine-protease activity of the Der p 1 allergen from house dust mite through a cysteine redox mechanism

Environmental proteases have been widely associated to the pathogenesis of allergic disorders. Der p 1, a cysteine-protease from house dust mite (HDM) Dermatophagoides pteronyssinus, constitutes one of the most clinically relevant indoor aeroallergens worldwide. Der p 1 protease activity depends on...

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Bibliographic Details
Main Authors: Juan Carlos López-Rodríguez, Juliana Manosalva, J. Daniel Cabrera-García, María M. Escribese, Mayte Villalba, Domingo Barber, Antonio Martínez-Ruiz, Eva Batanero
Format: Article
Language:English
Published: Elsevier 2019-09-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231719304744