Aberrantly methylated genes in human papillary thyroid cancer and their association with BRAF/RAS mutation.

Aberrantly methylated genes in human papillary thyroid cancer and their association with BRAF/RAS mutation.

Cancer arises through accumulation of epigenetic and genetic alteration. Aberrant promoter methylation is a common epigenetic mechanism of gene silencing in cancer cells. We here performed genome-wide analysis of DNA methylation of promoter regions by Infinium HumanMethylation27 BeadChip, using 14 c...

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Bibliographic Details
Main Authors: Yasuko eKikuchi, Eiichi eTsuji, Koichi eYagi, Keisuke eMatsusaka, Shingo eTsuji, Junichi eKurebayashi, Toshihisa eOgawa, Hiroyuki eAburatani, Atsushi eKaneda
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Genetics
Subjects:
DNA Methylation
thyroid cancer
Ras
BRAF
CIMP (CpG island methylator phenotype)
oncogene mutation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00271/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2013.00271/full

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