SIRT6 polymorphism rs117385980 is associated with longevity and healthy aging in Finnish men

SIRT6 polymorphism rs117385980 is associated with longevity and healthy aging in Finnish men

Abstract Background Sirtuin-6 (SIRT6) is involved in various crucial cellular pathways, being a key regulator of telomere structure, DNA repair, metabolism, transcriptional control and the NF-kappa B pathway. Sirt6 knock-out mice have been reported to develop typical features of aging and senescence...

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Bibliographic Details
Main Authors: Katariina Hirvonen, Hannele Laivuori, Jari Lahti, Timo Strandberg, Johan G. Eriksson, Peter Hackman
Format: Article
Language:English
Published: BMC 2017-04-01
Series:BMC Medical Genetics
Subjects:
SIRT6
Longevity
Polymorphism
Aging
Online Access:http://link.springer.com/article/10.1186/s12881-017-0401-z

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http://link.springer.com/article/10.1186/s12881-017-0401-z

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