Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB

Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB

Signalling endosomes are known to be essential for neuronal survival. Here the authors show that, in cultured hippocampal neurons and live Drosophilalarval motor neurons, neuronal activity increases the retrograde flux of signalling endosomes, and this coupling depends on TrkB activation.

Bibliographic Details
Main Authors: Tong Wang, Sally Martin, Tam H. Nguyen, Callista B. Harper, Rachel S. Gormal, Ramon Martínez-Mármol, Shanker Karunanithi, Elizabeth J. Coulson, Nick R. Glass, Justin J. Cooper-White, Bruno van Swinderen, Frédéric A. Meunier
Format: Article
Language:English
Published: Nature Publishing Group 2016-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms12976

Internet

https://doi.org/10.1038/ncomms12976

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