Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB
Signalling endosomes are known to be essential for neuronal survival. Here the authors show that, in cultured hippocampal neurons and live Drosophilalarval motor neurons, neuronal activity increases the retrograde flux of signalling endosomes, and this coupling depends on TrkB activation.
Main Authors: | Tong Wang, Sally Martin, Tam H. Nguyen, Callista B. Harper, Rachel S. Gormal, Ramon Martínez-Mármol, Shanker Karunanithi, Elizabeth J. Coulson, Nick R. Glass, Justin J. Cooper-White, Bruno van Swinderen, Frédéric A. Meunier |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2016-09-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms12976 |
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