NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast.

NMR structure of Hsp12, a protein induced by and required for dietary restriction-induced lifespan extension in yeast.

Dietary restriction (DR) extends lifespan in yeast, worms, flies and mammals, suggesting that it may act via conserved processes. However, the downstream mechanisms by which DR increases lifespan remain unclear. We used a gel based proteomic strategy to identify proteins whose expression was induced...

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Bibliographic Details
Main Authors: Andrew P Herbert, Michèle Riesen, Leanne Bloxam, Effie Kosmidou, Brian M Wareing, James R Johnson, Marie M Phelan, Stephen R Pennington, Lu-Yun Lian, Alan Morgan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3407059?pdf=render

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http://europepmc.org/articles/PMC3407059?pdf=render

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