The Networks of Genes Encoding Palmitoylated Proteins in Axonal and Synaptic Compartments Are Affected in PPT1 Overexpressing Neuronal-Like Cells

The Networks of Genes Encoding Palmitoylated Proteins in Axonal and Synaptic Compartments Are Affected in PPT1 Overexpressing Neuronal-Like Cells

CLN1 disease (OMIM #256730) is an early childhood ceroid-lipofuscinosis associated with mutated CLN1, whose product Palmitoyl-Protein Thioesterase 1 (PPT1) is a lysosomal enzyme involved in the removal of palmitate residues from S-acylated proteins. In neurons, PPT1 expression is also linked to syna...

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Bibliographic Details
Main Authors: Francesco Pezzini, Marzia Bianchi, Salvatore Benfatto, Francesca Griggio, Stefano Doccini, Rosalba Carrozzo, Arvydas Dapkunas, Massimo Delledonne, Filippo M. Santorelli, Maciej M. Lalowski, Alessandro Simonati
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
CLN1 disease
PPT1
differentiated neuroblastoma cells
RNA-seq
neuritogenesis
dysregulated genes
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00266/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00266/full

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