Bidirectionality and Compartmentation of Metabolic Fluxes Are Revealed in the Dynamics of Isotopomer Networks

Bidirectionality and Compartmentation of Metabolic Fluxes Are Revealed in the Dynamics of Isotopomer Networks

Isotope labeling is one of the few methods of revealing the in vivo bidirectionality and compartmentalization of metabolic fluxes within metabolic networks. We argue that a shift from steady state to dynamic isotopomer analysis is required to deal with these cellular complexities and provide a revie...

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Bibliographic Details
Main Authors: Marko Vendelin, Pearu Peterson, Toomas Paalme, David W. Schryer
Format: Article
Language:English
Published: MDPI AG 2009-04-01
Series:International Journal of Molecular Sciences
Subjects:
Metabolic network
isotopomer dynamics
MFA
mathematical modeling
compartmentalization
¹³C NMR
Online Access:http://www.mdpi.com/1422-0067/10/4/1697/

Internet

http://www.mdpi.com/1422-0067/10/4/1697/

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