Inhibition of TGFβ improves hematopoietic stem cell niche and ameliorates cancer-related anemia

Inhibition of TGFβ improves hematopoietic stem cell niche and ameliorates cancer-related anemia

Abstract Background Cancer cachexia is a wasting syndrome that is quite common in terminal-stage cancer patients. Cancer-related anemia is one of the main features of cancer cachexia and mostly results in a poor prognosis. The disadvantages of the current therapies are obvious, but few new treatment...

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Bibliographic Details
Main Authors: Boyan Wang, Yi Wang, Hainan Chen, Senyu Yao, Xiaofan Lai, Yuan Qiu, Jianye Cai, Yinong Huang, Xiaoyue Wei, Yuanjun Guan, Tao Wang, Jiancheng Wang, Andy Peng Xiang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Stem Cell Research & Therapy
Subjects:
Cancer-related anemia
Cachexia
Erythropoiesis
Hematopoietic stem cells niche
Mesenchymal stromal cells
TGFβ
Online Access:https://doi.org/10.1186/s13287-020-02120-9

Internet

https://doi.org/10.1186/s13287-020-02120-9

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