Hemophagocytic lymphohistiocytosis in children: pathogenesis and treatment

Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder in children, which is characterized by fever and hepatosplenomegaly associated with pancytopenia, hypertriglyceridemia and hypofibrinogenemia. Increased levels of various cytokines and soluble IL-2 receptors are biological markers of HLH. H...

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Bibliographic Details
Main Author: Eiichi eIshii
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-05-01
Series:Frontiers in Pediatrics
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fped.2016.00047/full