Live Cell Imaging Demonstrates Multiple Routes Toward a STAT1 Gain-of-Function Phenotype

Live Cell Imaging Demonstrates Multiple Routes Toward a STAT1 Gain-of-Function Phenotype

Signal transducer and activator of transcription 1 (STAT1) gain-of-function (GOF) mutations result in a primary immunodeficiency (PID) characterized typically by chronic mucocutaneous candidiasis (CMC), but a wider phenotypic range is reported and remains unexplained from a pathophysiological point-...

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Bibliographic Details
Main Authors: Simone Giovannozzi, Veerle Lemmens, Jelle Hendrix, Rik Gijsbers, Rik Schrijvers
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Immunology
Subjects:
STAT1
gain of function
live cell imaging
molecular mechanism
hyperphosphorylation
hypermorphic mutations
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01114/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01114/full

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