Brain Metabolic Profile after Intranasal vs. Intraperitoneal Clomipramine Treatment in Rats with Ultrasound Model of Depression

Brain Metabolic Profile after Intranasal vs. Intraperitoneal Clomipramine Treatment in Rats with Ultrasound Model of Depression

Background: Molecular mechanisms of depression remain unclear. The brain metabolome after antidepressant therapy is poorly understood and had not been performed for different routes of drug administration before the present study. Rats were exposed to chronic ultrasound stress and treated with intra...

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Bibliographic Details
Main Authors: Olga Abramova, Yana Zorkina, Timur Syunyakov, Eugene Zubkov, Valeria Ushakova, Artemiy Silantyev, Kristina Soloveva, Olga Gurina, Alexander Majouga, Anna Morozova, Vladimir Chekhonin
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:International Journal of Molecular Sciences
Subjects:
metabolome
rats
depressive-like behavior
hippocampus
frontal cortex
Online Access:https://www.mdpi.com/1422-0067/22/17/9598

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https://www.mdpi.com/1422-0067/22/17/9598

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