H3K36 Histone Methyltransferase Setd2 Is Required for Murine Embryonic Stem Cell Differentiation toward Endoderm

H3K36 Histone Methyltransferase Setd2 Is Required for Murine Embryonic Stem Cell Differentiation toward Endoderm

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Setd2 is known as a histone-H3K36-specific methyltransferase. However, its role in physiological function remains unclear. In this study, we show that Setd2 mainly regulates differentiation of murine embryonic stem cells (mESCs) toward primitive endoderm. Furthermore, we show that downregulated endo...

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Bibliographic Details
Main Authors: Yuanliang Zhang, Shugao Xie, Yan Zhou, Yinyin Xie, Ping Liu, Mingming Sun, Huasheng Xiao, Ying Jin, Xiaojian Sun, Zhu Chen, Qiuhua Huang, Saijuan Chen
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714007074

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http://www.sciencedirect.com/science/article/pii/S2211124714007074

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