An Overview of VPAC Receptors in Rheumatoid Arthritis: Biological Role and Clinical Significance

An Overview of VPAC Receptors in Rheumatoid Arthritis: Biological Role and Clinical Significance

The axis comprised by the Vasoactive Intestinal Peptide (VIP) and its G protein-coupled receptors (GPCRs), VPAC1, and VPAC2, belong to the B1 family and signal through Gs or Gq proteins. VPAC receptors seem to preferentially interact with Gs in inflammatory cells, rather than Gq, thereby stimulating...

Full description

Bibliographic Details
Main Authors: Rosa P. Gomariz, Yasmina Juarranz, Mar Carrión, Selene Pérez-García, Raúl Villanueva-Romero, Isidoro González-Álvaro, Irene Gutiérrez-Cañas, Amalia Lamana, Carmen Martínez
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Endocrinology
Subjects:
VPAC receptors
vasoactive intestinal peptide
rheumatoid arthritis
inflammation
autoimmunity
prognosis biomarker
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00729/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2019.00729/full

Similar Items