Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG

Evasion of Classical Complement Pathway Activation on Plasmodium falciparum-Infected Erythrocytes Opsonized by PfEMP1-Specific IgG

Members of the PfEMP1 protein family are expressed on the surface of P. falciparum-infected erythrocytes (IEs), where they contribute to the pathogenesis of malaria and are important targets of acquired immunity. Although the PfEMP1-specific antibody response is dominated by the opsonizing and compl...

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Bibliographic Details
Main Authors: Mads Delbo Larsen, Maria del Pilar Quintana, Sisse Bolm Ditlev, Rafael Bayarri-Olmos, Michael Fokuo Ofori, Lars Hviid, Peter Garred
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Immunology
Subjects:
malaria
complement
evasion
PfEMP1
antibodies
knobs
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.03088/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.03088/full

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