Context-dependent expression of a conditionally-inducible form of active Akt.

Context-dependent expression of a conditionally-inducible form of active Akt.

Akt kinases are key signaling components in proliferation-competent and post-mitotic cells. Here, we sought to create a conditionally-inducible form of active Akt for both in vitro and in vivo applications. We fused a ligand-responsive Destabilizing Domain (DD) derived from E. coli dihydrofolate red...

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Bibliographic Details
Main Authors: Soyeon Park, Robert E Burke, Tatyana Kareva, Nikolai Kholodilov, Pascaline Aimé, Thomas F Franke, Oren Levy, Lloyd A Greene
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6007834?pdf=render

Internet

http://europepmc.org/articles/PMC6007834?pdf=render

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