Lysosomal response in relation to α-synuclein pathology differs between Parkinson's disease and multiple system atrophy

Lysosomal response in relation to α-synuclein pathology differs between Parkinson's disease and multiple system atrophy

Intracellular deposition of pathologically altered α-synuclein mostly in neurons characterises Parkinson's disease (PD), while its accumulation predominantly in oligodendrocytes is a feature of multiple system atrophy (MSA). Recently a prion-like spreading of pathologic α-synuclein has been sug...

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Bibliographic Details
Main Authors: Gina Puska, Mirjam I. Lutz, Kinga Molnar, Günther Regelsberger, Gerda Ricken, Walter Pirker, Lajos Laszlo, Gabor G. Kovacs
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:Neurobiology of Disease
Subjects:
α-Synuclein
Cathepsin D
Endosome
Lysosome
Multiple system atrophy
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118300615

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http://www.sciencedirect.com/science/article/pii/S0969996118300615

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