Lysosomal response in relation to α-synuclein pathology differs between Parkinson's disease and multiple system atrophy
Intracellular deposition of pathologically altered α-synuclein mostly in neurons characterises Parkinson's disease (PD), while its accumulation predominantly in oligodendrocytes is a feature of multiple system atrophy (MSA). Recently a prion-like spreading of pathologic α-synuclein has been sug...
Main Authors: | Gina Puska, Mirjam I. Lutz, Kinga Molnar, Günther Regelsberger, Gerda Ricken, Walter Pirker, Lajos Laszlo, Gabor G. Kovacs |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2018-06-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996118300615 |
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