Upregulation of intratumoral HLA class I and peritumoral Mx1 in ulcerated melanomas

Upregulation of intratumoral HLA class I and peritumoral Mx1 in ulcerated melanomas

Before the era of immune checkpoint blockade, a meta-analysis encompassing fifteen trials reported that adjuvant IFN-α significantly reduces the risk of relapse and improves survival of ulcerated melanoma (UM) with no benefit for higher doses compared to lower doses. IFNa2b affects many cell intrins...

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Bibliographic Details
Main Authors: Daniëlle Verver, Vichnou Poirier-Colame, Gorana Tomasic, Khadija Cherif-Rebai, Dirk J. Grunhagen, Cornelis Verhoef, Stefan Suciu, Caroline Robert, Laurence Zitvogel, Alexander M.M. Eggermont
Format: Article
Language:English
Published: Taylor & Francis Group 2019-11-01
Series:OncoImmunology
Subjects:
melanoma
ulceration
immunohistochemistry
interferon
immune-editing
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1660121

Internet

http://dx.doi.org/10.1080/2162402X.2019.1660121

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