Identification of Cardiac Glycosides as Novel Inhibitors of eIF4A1-Mediated Translation in Triple-Negative Breast Cancer Cells

Identification of Cardiac Glycosides as Novel Inhibitors of eIF4A1-Mediated Translation in Triple-Negative Breast Cancer Cells

The eukaryotic translation initiation factor 4F complex (eIF4F) is a potential chemotherapeutic target in triple-negative breast cancer (TNBC). This complex regulates cap-dependent translational initiation and consists of three core proteins: eIF4E, eIF4G, and eIF4A1. In this study, we focus on repo...

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Bibliographic Details
Main Authors: Cory M. Howard, Matthew Estrada, David Terrero, Amit K. Tiwari, Dayanidhi Raman
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
eIF4A1
c-MYC
digoxin
bufalin
rocaglamide A
TNBC
Online Access:https://www.mdpi.com/2072-6694/12/8/2169

Internet

https://www.mdpi.com/2072-6694/12/8/2169

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