NOP receptor pharmacological profile - A dynamic mass redistribution study.

The Nociceptin/Orphanin FQ (N/OFQ) peptide NOP receptor is coupled to pertussis toxin (PTX)-sensitive G proteins (Gi/o) whose activation leads to the inhibition of both cAMP production and calcium channel activity, and to the stimulation of potassium currents. The label free dynamic mass redistribut...

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Bibliographic Details
Main Authors: Davide Malfacini, Katharina Simon, Claudio Trapella, Remo Guerrini, Nurulain T Zaveri, Evi Kostenis, Girolamo Calo'
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6117024?pdf=render