Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos

Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos

Summary: Mechanisms coordinating pancreatic β cell metabolism with insulin secretion are essential for glucose homeostasis. One key mechanism of β cell nutrient sensing uses the mitochondrial GTP (mtGTP) cycle. In this cycle, mtGTP synthesized by succinyl-CoA synthetase (SCS) is hydrolyzed via mitoc...

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Bibliographic Details
Main Authors: Sean R. Jesinkey, Anila K. Madiraju, Tiago C. Alves, OrLando H. Yarborough, Rebecca L. Cardone, Xiaojian Zhao, Yassmin Parsaei, Ali R. Nasiri, Gina Butrico, Xinran Liu, Anthony J. Molina, Austin M. Rountree, Adam S. Neal, Dane M. Wolf, John Sterpka, William M. Philbrick, Ian R. Sweet, Orian H. Shirihai, Richard G. Kibbey
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719308319

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http://www.sciencedirect.com/science/article/pii/S2211124719308319

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