ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition

ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition

Intrinsic resistance and RTK-RAS-MAPK pathway reactivation has limited the effectiveness of MEK and RAF inhibitors (MAPKi) in RAS- and RAF-mutant cancers. To identify genes that modulate sensitivity to MAPKi, we performed genome-scale CRISPR-Cas9 loss-of-function screens in two KRAS mutant pancreati...

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Bibliographic Details
Main Authors: Belinda Wang, Elsa Beyer Krall, Andrew James Aguirre, Miju Kim, Hans Ragnar Widlund, Mihir Bhavik Doshi, Ewa Sicinska, Rita Sulahian, Amy Goodale, Glenn Spencer Cowley, Federica Piccioni, John Gerard Doench, David Edward Root, William Chun Hahn
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Cell Reports
Subjects:
CIC
ATXN1L
ETS
MEK
MAPK
trametinib
KRAS
resistance
CRISPR-Cas9
cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717300682

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http://www.sciencedirect.com/science/article/pii/S2211124717300682

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