IFN-γ–STAT1–iNOS Induces Myeloid Progenitors to Acquire Immunosuppressive Activity

IFN-γ–STAT1–iNOS Induces Myeloid Progenitors to Acquire Immunosuppressive Activity

Autoimmune diseases often induce dysregulated hematopoiesis with altered number and function of hematopoietic stem and progenitor cells (HSPCs). However, there are limited studies on the direct regulation of HSPCs on T cells, which are often detrimental to autoimmunity. Here, we found that in a muri...

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Bibliographic Details
Main Authors: Shu-Han Yang, Liang Li, Yu-Qing Xie, Yuan Yao, Cai-Yue Gao, Liang-Huan Liao, Hong-Di Ma, M. Eric Gershwin, Zhe-Xiong Lian
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
immunosuppression
autoimmune disease
myeloid progenitors
T cells
bone marrow
IFN-γ
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01192/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01192/full

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