Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death

Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death

Abstract Pro-inflammatory cytokines are important mediators of islet inflammation, leading to beta cell death in type 1 diabetes. Although alterations in both endoplasmic reticulum (ER) and cytosolic free calcium levels are known to play a role in cytokine-mediated beta cell death, there are current...

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Bibliographic Details
Main Authors: Amy L. Clark, Kohsuke Kanekura, Zeno Lavagnino, Larry D. Spears, Damien Abreu, Jana Mahadevan, Takuya Yagi, Clay F. Semenkovich, David W. Piston, Fumihiko Urano
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-017-05935-4

Internet

https://doi.org/10.1038/s41598-017-05935-4

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