Structure-Guided Creation of an Anti-HA Stalk Antibody F11 Derivative That Neutralizes Both F11-Sensitive and -Resistant Influenza A(H1N1)pdm09 Viruses

Structure-Guided Creation of an Anti-HA Stalk Antibody F11 Derivative That Neutralizes Both F11-Sensitive and -Resistant Influenza A(H1N1)pdm09 Viruses

The stalk domain of influenza virus envelope glycoprotein hemagglutinin (HA) constitutes the axis connecting the head and transmembrane domains, and plays pivotal roles in conformational rearrangements of HA for virus infection. Here we characterized molecular interactions between the anti-HA stalk...

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Bibliographic Details
Main Authors: Osamu Kotani, Yasushi Suzuki, Shinji Saito, Akira Ainai, Akira Ueno, Takuya Hemmi, Kaori Sano, Koshiro Tabata, Masaru Yokoyama, Tadaki Suzuki, Hideki Hasegawa, Hironori Sato
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Viruses
Subjects:
influenza virus
anti-HA stalk antibody
molecular interactions
molecular dynamics simulation
antibody modification
neutralization assay
Online Access:https://www.mdpi.com/1999-4915/13/9/1733

Internet

https://www.mdpi.com/1999-4915/13/9/1733

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