Cooperative p16 and p21 action protects female astrocytes from transformation

Cooperative p16 and p21 action protects female astrocytes from transformation

Abstract Mechanisms underlying sex differences in cancer incidence are not defined but likely involve dimorphism (s) in tumor suppressor function at the cellular and organismal levels. As an example, sexual dimorphism in retinoblastoma protein (Rb) activity was shown to block transformation of femal...

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Bibliographic Details
Main Authors: Najla Kfoury, Tao Sun, Kwanha Yu, Nathan Rockwell, Kelsey L. Tinkum, Zongtai Qi, Nicole M. Warrington, Peter McDonald, Anuradha Roy, Scott J. Weir, Carrie A. Mohila, Benjamin Deneen, Joshua B. Rubin
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Acta Neuropathologica Communications
Subjects:
Sex differences
Glioblastoma
Glioma
Rb
p16
p21
Online Access:http://link.springer.com/article/10.1186/s40478-018-0513-5

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http://link.springer.com/article/10.1186/s40478-018-0513-5

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