Asymmetric Fc Engineering for Bispecific Antibodies with Reduced Effector Function

Asymmetric Fc Engineering for Bispecific Antibodies with Reduced Effector Function

Asymmetric bispecific antibodies are a rapidly expanding therapeutic antibody class, designed to recognize two different target epitopes concurrently to achieve novel functions not available with normal antibodies. Many therapeutic designs require antibodies with reduced or silenced effector functio...

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Bibliographic Details
Main Authors: Eric Escobar-Cabrera, Paula Lario, Jason Baardsnes, Joseph Schrag, Yves Durocher, Surjit Dixit
Format: Article
Language:English
Published: MDPI AG 2017-05-01
Series:Antibodies
Subjects:
Fc engineering
asymmetric bispecific antibody
ion exchange chromatography
knock-out effector function
Online Access:http://www.mdpi.com/2073-4468/6/2/7

Internet

http://www.mdpi.com/2073-4468/6/2/7

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