A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone to treat recurrent pregnancy loss in women with undifferentiated connective tissue diseases: protocol for the Immunosuppressant regimens for LIving FEtuses (ILIFE) trial

A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone to treat recurrent pregnancy loss in women with undifferentiated connective tissue diseases: protocol for the Immunosuppressant regimens for LIving FEtuses (ILIFE) trial

Abstract Background Undifferentiated connective tissue disease (UCTD) is known to induce adverse pregnancy outcomes and even recurrent spontaneous abortion (RSA) by placental vascular damage and inflammation activation. Anticoagulation can prevent pregnancy morbidities. However, it is unknown whethe...

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Bibliographic Details
Main Authors: Shaoying Yang, Ruoning Ni, Yikang Lu, Suli Wang, Feng Xie, Chunyan Zhang, Liangjing Lu
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Trials
Subjects:
Prednisone
Hydroxychloroquine
Recurrent pregnancy loss
Recurrent spontaneous abortion
Undifferentiated connective tissue disease
Randomized controlled trial
Online Access:http://link.springer.com/article/10.1186/s13063-020-04716-1

Internet

http://link.springer.com/article/10.1186/s13063-020-04716-1

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