A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain

A novel cholesterol stain reveals early neuronal cholesterol accumulation in the Niemann-Pick type C1 mouse brain

Niemann-Pick type C (NPC) is a neurodegenerative disorder characterized by progressive accumulation of cholesterol, gangliosides, and other lipids in the central nervous system and visceral organs. In the NPC1 mouse model, neurodegeneration and neuronal cell loss occur before postnatal day 21. Wheth...

Full description

Bibliographic Details
Main Authors: Patrick C. Reid, Naomi Sakashita, Shigeki Sugii, Yoshiko Ohno-Iwashita, Yukiko Shimada, William F. Hickey, Ta-Yuan Chang
Format: Article
Language:English
Published: Elsevier 2004-03-01
Series:Journal of Lipid Research
Subjects:
intracellular cholesterol accumulation
Niemann-Pick Disease
neuron
astrocyte
Purkinje cell
neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520318873

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520318873

Similar Items