KYP-2047, an Inhibitor of Prolyl-Oligopeptidase, Reduces GlioBlastoma Proliferation through Angiogenesis and Apoptosis Modulation

KYP-2047, an Inhibitor of Prolyl-Oligopeptidase, Reduces GlioBlastoma Proliferation through Angiogenesis and Apoptosis Modulation

Glioblastoma (GB) is the most aggressive tumor of the central nervous system (CNS), characterized by excessive proliferation, necrosis and invasiveness. The survival rate for patients with GB still remains low. Angiogenesis and apoptosis play a key role in the development of GB. Thus, the modulation...

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Bibliographic Details
Main Authors: Sarah Adriana Scuderi, Giovanna Casili, Alessio Ardizzone, Stefano Forte, Lorenzo Colarossi, Serena Sava, Irene Paterniti, Emanuela Esposito, Salvatore Cuzzocrea, Michela Campolo
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
glioblastoma (GB)
prolyl-oligopeptidase (POP)
vascular endothelial growth factor (VEGF)
transforming growth factor-β (TGF-β)
angiopoietin (Ang)
endothelial nitric oxide synthase (eNOS)
Online Access:https://www.mdpi.com/2072-6694/13/14/3444

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https://www.mdpi.com/2072-6694/13/14/3444

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