Synthesis and Molecular Modelling Studies of New 1,3-Diaryl-5-Oxo-Proline Derivatives as Endothelin Receptor Ligands

Synthesis and Molecular Modelling Studies of New 1,3-Diaryl-5-Oxo-Proline Derivatives as Endothelin Receptor Ligands

The synthesis of seventeen new 1,3-diaryl-5-oxo-proline derivatives as endothelin receptor (ETR) ligands is described. The structural configuration of the new molecules was determined by analyzing selected signals in proton NMR spectra. In vitro binding assays of the human ET<sub>A</sub>...

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Bibliographic Details
Main Authors: Sebastiano Intagliata, Mohamed A. Helal, Luisa Materia, Valeria Pittalà, Loredana Salerno, Agostino Marrazzo, Alfredo Cagnotto, Mario Salmona, Maria N. Modica, Giuseppe Romeo
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
endothelin receptors
ET<sub>A</sub> ligands
1,3-diaryl-5-oxo-proline derivatives
homology modeling
molecular docking
Online Access:https://www.mdpi.com/1420-3049/25/8/1851

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https://www.mdpi.com/1420-3049/25/8/1851

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